Article
DNA polymerase β prevents AID-instigated mutagenic non-canonical mismatch DNA repair
2020-01-31
Abstract excerpt
<h4>ABSTRACT</h4> In B cells, the error-prone repair of activation-induced cytidine deaminase (AID)-induced lesions in immunoglobulin variable genes cause somatic hypermutation (SHM) of antibody genes. Due to clonal selection in the germinal centers (GC) this active mutation process provides the molecular basis for antibody affinity maturation. AID deaminates cytosine (C) to create uracil (U) in DNA. Typically, t...
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Identifiers and source
- Literature Corpus work
- 89456cdf-b40c-526e-a3b0-d610037118ec
- DOI
- 10.1101/2020.01.30.926964