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Article

Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases.

DNA repair - 1 Feb 2016

Zanotti Kimberly J, Gearhart Patricia J

Abstract excerpt

The enzyme activation-induced deaminase (AID) targets the immunoglobulin loci in activated B cells and creates DNA mutations in the antigen-binding variable region and DNA breaks in the switch region through processes known, respectively, as somatic hypermutation and class switch recombination. AID deaminates cytosine to uracil in DNA to create a U:G mismatch. During somatic hypermutation, the MutSα complex binds...

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Source

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Identifiers

PMID: 26719140
DOI: 10.1016/j.dnarep.2015.11.011
PMCID: PMC4740194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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