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AID Biology: A pathological and clinical perspective

21 Sept 2017

Abstract excerpt

Activation-induced cytidine deaminase (AID), primarily expressed in activated mature B lymphocytes in germinal centers, is the key factor in adaptive immune response against foreign antigens. AID is responsible for producing high-affinity and high-specificity antibodies against an infectious agent, through the physiological DNA alteration processes of antibody genes by somatic hypermutation (SHM) and class-switch...

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PMID: 28933967
DOI: 10.1080/08830185.2017.1369980

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