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Article

Base Excision Repair in the Immune System: Small DNA Lesions With Big Consequences

29 May 2020

Abstract excerpt

The integrity of the genome is under constant threat of environmental and endogenous agents that cause DNA damage. Endogenous damage is particularly pervasive, occurring at an estimated rate of 10,000-30,000 per cell/per day, and mostly involves chemical DNA base lesions caused by oxidation, depurination, alkylation and deamination. The base excision repair (BER) pathway is primary responsible for removing and...

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PMID: 32547565
DOI: 10.3389/fimmu.2020.01084

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