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Mutating for Good: DNA Damage Responses During Somatic Hypermutation

12 Mar 2019

Abstract excerpt

Somatic hypermutation (SHM) of immunoglobulin (Ig) genes plays a key role in antibody mediated immunity. SHM in B cells provides the molecular basis for affinity maturation of antibodies. In this way SHM is key in optimizing antibody dependent immune responses. SHM is initiated by targeting the Activation-Induced Cytidine Deaminase (AID) to rearranged V(D)J and switch regions of Ig genes. The mutation rate of...

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PMID: 30915081
DOI: 10.3389/fimmu.2019.00438

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