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Article

Mismatch-mediated error prone repair at the immunoglobulin genes.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Dec 2011

Chahwan Richard, Edelmann Winfried, Scharff Matthew D, Roa Sergio

Abstract excerpt

The generation of effective antibodies depends upon somatic hypermutation (SHM) and class-switch recombination (CSR) of antibody genes by activation induced cytidine deaminase (AID) and the subsequent recruitment of error prone base excision and mismatch repair. While AID initiates and is required for SHM, more than half of the base changes that accumulate in V regions are not due to the direct deamination of dC...

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Source

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Identifiers

PMID: 22100214
DOI: 10.1016/j.biopha.2011.09.001
PMCID: PMC3235044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA Lesions and Repair in Immunoglobulin Class Switch Recombination and Somatic HypermutationSemantic proximity Read ↗

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Mutating for Good: DNA Damage Responses During Somatic HypermutationSemantic proximity Read ↗

Base Excision Repair in the Immune System: Small DNA Lesions With Big ConsequencesSemantic proximity Read ↗

Targeting of AID-mediated sequence diversification to immunoglobulin genes.Semantic proximity Read ↗

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