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Article

Taming AID mutator activity in somatic hypermutation.

Trends in biochemical sciences - 1 Jul 2024

Qin Yining, Meng Fei-Long

Abstract excerpt

Activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) by introducing base substitutions into antibody genes, a process enabling antibody affinity maturation in immune response. How a mutator is tamed to precisely and safely generate programmed DNA lesions in a physiological process remains unsettled, as its dysregulation drives lymphomagenesis. Recent research has revealed several...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Identifiers

PMID: 38614818
DOI: 10.1016/j.tibs.2024.03.011

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