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Article

AIDing antibody diversity by error-prone mismatch repair.

Seminars in immunology - 1 Aug 2012

Chahwan Richard, Edelmann Winfried, Scharff Matthew D, Roa Sergio

Abstract excerpt

The creation of a highly diverse antibody repertoire requires the synergistic activity of a DNA mutator, known as activation-induced deaminase (AID), coupled with an error-prone repair process that recognizes the DNA mismatch catalyzed by AID. Instead of facilitating the canonical error-free response, which generally occurs throughout the genome, DNA mismatch repair (MMR) participates in an error-prone repair...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22703640
DOI: 10.1016/j.smim.2012.05.005
PMCID: PMC3422444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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