DNA Lesions and Repair in Immunoglobulin Class Switch Recombination and Somatic Hypermutation

Abstract excerpt

Immunoglobulin (Ig) gene somatic hypermutation (SHM) and class switch DNA recombination (CSR) are critical for the maturation of the antibody response. These processes endow antibodies with increased antigen-binding affinity and acquisition of new biological effector functions, thereby underlying the generation of memory B cells and plasma cells. They are dependent on the generation of specific DNA lesions and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA Repair Mechanisms
• Share to Hematopoietic Stem Cell Transplantation
• Share to T-cell and B-cell Immunology