Article

Systematic screen of PKR reveals genetic variants that broadly evade divergent viral pseudosubstrate inhibitors

2026-08-16

Abstract excerpt

<h4>ABSTRACT</h4> Evolutionary arms races can arise at the contact surfaces between host and viral proteins, producing dynamic spaces in which genetic variants are continually pursued. However, the sampling of genetic variation must be balanced with the need to maintain protein function. A striking case is given by protein kinase R (PKR), a member of the mammalian innate immune system. PKR detects viral replicati...

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Literature Corpus work: 88e69b65-5343-5bb2-b629-f5dd4ec72c14
DOI: 10.64898/2026.08.11.744216

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