Article

Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic

2024-06-02

Abstract excerpt

<h4>ABSTRACT</h4> Evolutionary arms races can arise at the contact surfaces between host and viral proteins, producing dynamic spaces in which genetic variants are continually pursued. However, the sampling of genetic variation must be balanced with the need to maintain protein function. A striking case is given by protein kinase R (PKR), a member of the mammalian innate immune system. PKR detects viral replicati...

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Literature Corpus work: 3ecaf668-3b55-581a-8012-d1d7a7f3ba72
DOI: 10.1101/2024.05.29.596416

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