Article

Effective repurposed antivirals against an emerging virus

2025-10-14

Abstract excerpt

The ongoing global monkeypox virus (MPXV) outbreak urgently needs effective medications, which be accelerated through drug repurposing. However, it is challenging to poinpoint protein targets. Here we introduce a novel method rooted in molecular evolutionary theory for quick drug target identification for MPXV. It identifies drug targets as positively selected genes of viral proteins which bind host proteins. From...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ec876e7d-aa1a-5d9b-acfe-99c9f3ae742a
DOI: 10.1101/2025.10.12.681938

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effective repurposed antivirals against an emerging virusDOI 10.1101/2025.10.12.681938Read

<i>In silico</i> repurposed drugs against monkeypox virusSemantic proximity Read

A Computational Framework of Host-Based Drug Repositioning for Broad-Spectrum Antivirals against RNA VirusesSemantic proximity Read

Drug combinations proposed by machine learning on genes/proteins to improve the efficacy of Tecovirimat in the treatment of Monkeypox: A Systematic Review and Network Meta-analysisSemantic proximity Read

The Hunt for antipox compounds against Monkeypox Virus Thymidylate Kinase and scaffolding protein leveraging Pharmacophore modeling, molecular docking, ADMET Studies, and molecular dynamics simulation studiesSemantic proximity Read

Deciphering the complete human-monkeypox virus interactome: Identifying immune responses and potential drug targetsSemantic proximity Read

A computational framework of host-based drug repositioning for broad-spectrum antivirals against RNA virusesSemantic proximity Read

Identification of FDA-approved drugs with triple targeting mode of action for the treatment of Monkeypox: a high throughput virtual screening studySemantic proximity Read

Comparative genomics and integrated system biology approach unveiled undirected phylogeny patterns, mutational hot spots, functional patterns and molecule repurposing for monkey pox virusSemantic proximity Read

Potential of Acyclovir, Allopurinol and B Vitamins for the Treatment of Mpox Viral Infection; Insight from Molecular Docking of the Mpox Virus Multi-Domain DNA PolymeraseSemantic proximity Read

Discovery and Development of Safe-in-Man Broad-Spectrum Antiviral AgentsSemantic proximity Read

Comparative genomics and integrated system biology approach unveiled undirected phylogeny patterns, mutational hotspots, functional patterns, and molecule repurposing for monkeypox virus.Semantic proximity Read

Structural and functional similarities in bunyaviruses: Perspectives for pan‐bunya antiviralsSemantic proximity Read