Article

Combinatorial mutagenesis of rapidly-evolving residues yields super-restrictor antiviral proteins

2019-02-22

Abstract excerpt

Antagonistic interactions drive host-virus evolutionary arms-races, which often manifest as recurrent amino acid changes ( i.e ., positive selection) at their protein-protein interaction interfaces. Here, we investigated whether combinatorial mutagenesis of positions under positive selection in a host antiviral protein could enhance its restrictive properties. We tested ~700 variants of human MxA, generated by co...

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Literature Corpus work: 2d6a149e-0e2b-578c-8b93-4fd867e5d1b1
DOI: 10.1101/557264

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