Article
Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein.
Proceedings of the National Academy of Sciences of the United States of America - 4 Nov 2008
Seo Eun Joo, Liu Furong, Kawagishi-Kobayashi Makiko, Ung Tekly L, Cao Chune, Dar Arvin C, Sicheri Frank, Dever Thomas E
Abstract excerpt
As part of the mammalian cell innate immune response, the double-stranded RNA activated protein kinase PKR phosphorylates the translation initiation factor eIF2alpha to inhibit protein synthesis and thus block viral replication. Poxviruses including vaccinia and smallpox viruses express PKR inhibitors such as the vaccinia virus K3L protein that resembles the N-terminal substrate-targeting domain of eIF2alpha....
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