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Article

Deleterious single nucleotide polymorphisms of protein kinase R identified by the computational approach.

Molecular immunology - 1 Sept 2018

Melzer Anna Maria, Palanisamy Navaneethan

Abstract excerpt

The human protein kinase R (PKR) recognizes invading RNA viruses and mediates the antiviral immune response by phosphorylating the eukaryotic translation initiation factor 2α (eIF-2α), thus blocking protein translation in infected cells and thus preventing viral replication. The observation that individuals show different degrees of susceptibility to viral infections gives rise to the hypothesis that single...

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PMID: 29879548
DOI: 10.1016/j.molimm.2018.05.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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