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Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKR

14 Jan 2021

Abstract excerpt

The antiviral protein kinase R (PKR) is an important host restriction factor, which poxviruses must overcome to productively infect host cells. To inhibit PKR, many poxviruses encode a pseudosubstrate mimic of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2), designated K3 in vaccinia virus. Although the interaction between PKR and eIF2α is highly conserved, some K3 orthologs from...

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PMID: 33444388
DOI: 10.1371/journal.ppat.1009183

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