Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic.

doi:10.7554/eLife.99575

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Article

Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic.

eLife - 12 Nov 2024

Chambers Michael James, Scobell Sophia B, Sadhu Meru J

Abstract excerpt

Evolutionary arms races can arise at the contact surfaces between host and viral proteins, producing dynamic spaces in which genetic variants are continually pursued.  However, the sampling of genetic variation must be balanced with the need to maintain protein function. A striking case is given by protein kinase R (PKR), a member of the mammalian innate immune system. PKR detects viral replication within the...

Topics

eIF-2 Kinase
Humans
Vaccinia virus
Viral Proteins
Eukaryotic Initiation Factor-2
Protein Domains
Polymorphism, Single Nucleotide
Evolution, Molecular
Poxviridae

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PMID: 39531012
DOI: 10.7554/eLife.99575
PMCID: PMC11556786

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