Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic.

eLife - 12 Nov 2024

Chambers Michael James, Scobell Sophia B, Sadhu Meru J

Abstract excerpt

Evolutionary arms races can arise at the contact surfaces between host and viral proteins, producing dynamic spaces in which genetic variants are continually pursued.  However, the sampling of genetic variation must be balanced with the need to maintain protein function. A striking case is given by protein kinase R (PKR), a member of the mammalian innate immune system. PKR detects viral replication within the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to eIF-2 Kinase
Share to Eukaryotic Initiation Factor-2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Polymorphism, Single Nucleotide

Share to Protein Domains

Share to Vaccinia virus

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39531012
DOI: 10.7554/eLife.99575
PMCID: PMC11556786

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic.PMID 39531012Read ↗

Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimicSemantic proximity Read ↗

Systematic screen of PKR reveals genetic variants that broadly evade divergent viral pseudosubstrate inhibitorsSemantic proximity Read ↗

Systematic characterization of the local evolutionary space available to human PKR and vaccinia virus K3Semantic proximity Read ↗

Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors.Semantic proximity Read ↗

A Single Amino Acid Dictates Protein Kinase R Susceptibility to Unrelated Viral Antagonists.Semantic proximity Read ↗

Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein.Semantic proximity Read ↗

Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKRSemantic proximity Read ↗

Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKRSemantic proximity Read ↗

Deleterious single nucleotide polymorphisms of protein kinase R identified by the computational approach.Semantic proximity Read ↗

Adaptive duplication and functional diversification of Protein kinase R contribute to the uniqueness of bat-virus interactionsSemantic proximity Read ↗

Emergence of a Viral RNA Polymerase Variant during Gene Copy Number Amplification Promotes Rapid Evolution of Vaccinia Virus.Semantic proximity Read ↗

Baculovirus protein PK2 subverts eIF2α kinase function by mimicry of its kinase domain C-lobe.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.