Article

Systematic characterization of the local evolutionary space available to human PKR and vaccinia virus K3

2023-11-22

Abstract excerpt

The interfaces between host and viral proteins can be dynamic spaces in which genetic variants are continually pursued, giving rise to evolutionary arms races. One such scenario is found between the mammalian innate immunity protein PKR (protein kinase R) and the poxvirus antagonist K3. Once activated, PKR phosphorylates the natural substrate eIF2α, which halts protein synthesis within the cell and prevents viral...

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Literature Corpus work: 6d2af897-42ed-52b5-b67c-a832ab99d215
DOI: 10.1101/2023.11.21.568178

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