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Article

Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors.

Nature structural & molecular biology - 1 Jan 2009

Rothenburg Stefan, Seo Eun Joo, Gibbs James S, Dever Thomas E, Dittmar Katharina

Abstract excerpt

Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2), leading to inhibition of translation and viral replication. We report fast evolution of the PKR kinase domain in vertebrates, coupled with positive selection of specific sites. Substitution of positively selected residues in human PKR with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19043413
DOI: 10.1038/nsmb.1529
PMCID: PMC3142916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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