High content screening and computational prediction reveal viral genes that suppress innate immune response

Abstract excerpt

<h4>ABSTRACT</h4> Suppression of the host innate immune response is a critical aspect of viral replication. Upon infection, viruses may introduce one or more proteins that inhibit key immune pathways, such as the type I interferon pathway. However, the ability to predict and evaluate viral protein bioactivity on targeted pathways remains challenging and is typically done on a single virus/gene basis. Here, we pre...

Topics

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• Animal Virus Infections Studies
• Cytomegalovirus and herpesvirus research
• interferon and immune responses
• Mosquito-borne diseases and control
• RNA and protein synthesis mechanisms
• vaccines and immunoinformatics approaches
• Viral Infections and Immunology Research
• Viral Infections and Outbreaks Research

Identifiers and source

Literature Corpus work

59b766f6-f4e3-592e-9b91-c103af181cc3

DOI

10.1101/2021.12.14.472572