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Article

A Single Amino Acid Dictates Protein Kinase R Susceptibility to Unrelated Viral Antagonists.

PLoS pathogens - 1 Oct 2016

Carpentier Kathryn S, Esparo Nicolle M, Child Stephanie J, Geballe Adam P

Abstract excerpt

During millions of years of coevolution with their hosts, cytomegaloviruses (CMVs) have succeeded in adapting to overcome host-specific immune defenses, including the protein kinase R (PKR) pathway. Consequently, these adaptations may also contribute to the inability of CMVs to cross species barriers. Here, we provide evidence that the evolutionary arms race between the antiviral factor PKR and its CMV antagonist...

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Identifiers

PMID: 27780231
DOI: 10.1371/journal.ppat.1005966
PMCID: PMC5079575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A Single Amino Acid Dictates Protein Kinase R Susceptibility to Unrelated Viral Antagonists.PMID 27780231Read ↗

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