Article

Cardiomyocyte-restricted expression of IL11 causes cardiac fibrosis, inflammation, and dysfunction

2023-05-23

Abstract excerpt

<h4> Abstract </h4> Background: Cardiac fibrosis is a common pathological process in heart disease and represents a therapeutic target. TGFβ is the canonical driver of cardiac fibrosis and was recently shown to be dependent on IL11 for its profibrotic effects in fibroblasts. In the opposite direction, recombinant human IL11 has been reported as anti-fibrotic and also anti- inflammatory in the mouse heart. <h4>Ob...

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Literature Corpus work: 88a55221-4d32-58c2-ab68-18c5cd8ac432
DOI: 10.1101/2023.05.23.541928

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