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Article

IL-11 is a therapeutic target in idiopathic pulmonary fibrosis

2018-06-02

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) remains a progressive disease despite best medical management. We previously identified IL-11 as a critical factor for cardiovascular fibrosis and examine here its role in pulmonary fibrosis. IL-11 is consistently upregulated in IPF genomic datasets, which we confirmed by histology. Pulmonary fibroblasts stimulated with IL-11 transform into invasive myofibroblasts whereas fibro...

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Literature Corpus work
26d36d06-8c45-5e15-b4b6-cb2ada1de34f
DOI
10.1101/336537
Open publication

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