Article

Epicardial contributions to fibro-inflammatory signaling in a Pkp2-deficient arrhythmogenic cardiomyopathy model

2025-10-09

Abstract excerpt

<h4>Background</h4> Arrhythmogenic Cardiomyopathy (ACM) is an inherited disease that is characterized by lethal ventricular arrhythmias stemming from myocyte dysfunction. ACM is associated with considerable subepicardial fibrosis and inflammation with right ventricle predominance. Most cases of gene positive ACM are caused by a desmosome protein mutation, with plakophilin-2 ( Pkp2 ) mutations being most common....

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Literature Corpus work: c768aeda-2c99-5863-ad9f-41510f23079a
DOI: 10.1101/2025.10.08.680826

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