Article

Identification of CD4 <sup>+</sup> Sub-population of Resident Cardiac Fibroblasts Linked to Myocardial Fibrosis

2021-02-26

Abstract excerpt

Infiltration with inflammatory T-cells and accumulation of cardiac myofibroblasts are hallmarks of cardiac fibrosis and maladaptive remodeling. The origin, identity, and functions of the resident cardiac cells involved in this process are, however, unclear. To determine the identity of cells contained in regions exhibiting fibrosis, mass cytometry profiling was performed using resident human ventricular cardiac fi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ba1aea98-07a8-5ef3-b234-5e26e005a9ec
DOI: 10.1101/2021.02.26.433023

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of CD4 <sup>+</sup> Sub-population of Resident Cardiac Fibroblasts Linked to Myocardial FibrosisDOI 10.1101/2021.02.26.433023Read

The Role of Cardiac Fibroblast Heterogeneity in Myocardial Fibrosis and Its Novel Therapeutic PotentialSemantic proximity Read

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart FailureSemantic proximity Read

Defining Transcriptomic Heterogeneity between Left and Right Ventricle-Derived Cardiac FibroblastsSemantic proximity Read

Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac FibrosisSemantic proximity Read

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injurySemantic proximity Read

Integrative Single-Cell Analysis of Cardiomyopathy Identifies Differences in Cell Stemness and Transcriptional Regulatory Networks among Fibroblast SubpopulationsSemantic proximity Read

Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in murine heart failure with preserved ejection fractionSemantic proximity Read

Cardiac fibroblast sub-types in vitro reflect pathological cardiac remodeling in vivoSemantic proximity Read

Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesisSemantic proximity Read

Macrophages and fibroblasts in cardiac fibrosis: interactions and transformationSemantic proximity Read

Deciphering Cell-Type-Specific Gene Expression Signatures of Cardiac Diseases Through Reconstruction of Bulk TranscriptomesSemantic proximity Read

Diverse origins and activation of fibroblasts in cardiac fibrosisSemantic proximity Read