Article

Consequences of PDGFRα <sup>+</sup> fibroblast reduction in adult murine hearts

2021-05-08

Abstract excerpt

Fibroblasts produce the majority of collagen in the heart and are thought to regulate extracellular matrix (ECM) turnover. Although fibrosis accompanies many cardiac pathologies and is generally deleterious, the role of fibroblasts in maintaining the basal ECM network and in fibrosis in vivo is poorly understood. We genetically ablated fibroblasts in mice to evaluate the impact on homeostasis of adult ECM and car...

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Literature Corpus work: 0ec0c858-8182-5598-b946-c8f2cc6dbf5f
DOI: 10.1101/2021.05.07.443103

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