Article

Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis

2023-01-26

Abstract excerpt

<title>Abstract</title> <p>Inflammation and tissue fibrosis co-exist and are causally linked to organ dysfunction. However, the molecular mechanisms driving immune-fibroblast crosstalk in human cardiac disease remains unexplored and there are currently no therapeutics to target fibrosis. Here, we performed multi-omic single-cell gene expression, epitope mapping, and chromatin accessibility profiling in 38 donors,...

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Literature Corpus work: b3e883e4-bb6d-5d5b-b3b9-67c1477cde68
DOI: 10.21203/rs.3.rs-2402606/v1

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