Article

Adventitial leptin receptor-expressing fibroblasts are preferential contributors to fibrotic remodeling of the heart post infarction

2025-10-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Cardiac fibrosis, a hallmark of heart failure and an unmet clinical need, arises from pathological activation of pre-existing cardiac fibroblasts (CFs), but the contribution of CF heterogeneity to this process remains unclear. <h4>Methods</h4> Murine models were used to lineage trace or deplete a specific sub-population of CFs at baseline and after myocardial infarction (M...

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Literature Corpus work: 8f636a35-baac-5514-bb68-f688cbbaa4f1
DOI: 10.1101/2025.10.14.682477

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