Article

Interleukin 11 therapy causes acute heart failure and its use in patients should be reconsidered

2023-10-01

Abstract excerpt

<h4>Background</h4> Interleukin 11 (IL11) was initially thought important for platelet production, which led to recombinant IL11 being developed as a drug to treat thrombocytopenia. IL11 was later found to be redundant for haematopoiesis and its use in patients is associated with unexplained cardiac side effects. Here we identify previously unappreciated and direct cardiomyocyte toxicities associated with IL11 th...

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Literature Corpus work: 4d8d5731-8213-5dfe-bf19-5b01531c3f94
DOI: 10.1101/2023.09.30.560259

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