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Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

26 Mar 2019

Abstract excerpt

Besides cardiomyocytes (CM), the heart contains numerous interstitial cell types which play key roles in heart repair, regeneration and disease, including fibroblast, vascular and immune cells. However, a comprehensive understanding of this interactive cell community is lacking. We performed single-cell RNA-sequencing of the total non-CM fraction and enriched (Pdgfra-GFP+) fibroblast lineage cells from murine...

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PMID: 30912746
DOI: 10.7554/elife.43882

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