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Article

Computational analysis of molecular basis of 1:1 interactions of NRG-1beta wild-type and variants with ErbB3 and ErbB4.

Proteins - 1 Jun 2005

Luo Cheng, Xu Lingfei, Zheng Suxin, Luo Xiaomin, Shen Jianhua, Jiang Hualiang, Liu Xifu, Zhou Mingdong

Abstract excerpt

The neuregulin/ErbB system is a growth factor/receptor cascade that has been proven to be essential in the development of the heart and the sympathetic nervous system. However, the basis of the specificity of ligand-receptor recognition remains to be elucidated. In this study, the structures of NRG-1beta/ErbB3 and NRG-1beta/ErbB4 complexes were modeled based on the available structures of the homologous proteins....

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Identifiers

PMID: 15822127
DOI: 10.1002/prot.20443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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