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Article

A function-structure model for NGF-activated TRK.

The EMBO journal - 15 Dec 1998

Cunningham M E, Greene L A

Abstract excerpt

Mechanisms regulating transit of receptor tyrosine kinases (RTKs) from inactive to active states are incompletely described, but require autophosphorylation of tyrosine(s) within a kinase domain 'activation loop'. Here, we employ functional biological assays with mutated TRK receptors to assess a 'switch' model for RTK activation. In this model: (i) ligand binding stimulates activation loop tyrosine...

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Identifiers

PMID: 9857185
DOI: 10.1093/emboj/17.24.7282
PMCID: PMC1171074

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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