Article
A function-structure model for NGF-activated TRK.
The EMBO journal - 15 Dec 1998
Cunningham M E, Greene L A
Abstract excerpt
Mechanisms regulating transit of receptor tyrosine kinases (RTKs) from inactive to active states are incompletely described, but require autophosphorylation of tyrosine(s) within a kinase domain 'activation loop'. Here, we employ functional biological assays with mutated TRK receptors to assess a...
Topics
- 3T3 Cells
- Animals
- Arginine
- Biological Assay
- Catalytic Domain
- Enzyme Activation
- Ligands
- Lysine
- Mice
- Models, Molecular
- Mutation
- Nerve Growth Factors
- Neurites
- PC12 Cells
- Phosphorylation
- Phosphotyrosine
- Protein Conformation
- Rats