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Article

Piconewton-Scale Analysis of Ras-BRaf Signal Transduction with Single-Molecule Force Spectroscopy.

Small (Weinheim an der Bergstrasse, Germany) - 1 Oct 2017

Lim Chae-Seok, Wen Cheng, Sheng Yanghui, Wang Guangfu, Zhou Zhuan, Wang Shiqiang, Zhang Huaye, Ye Anpei, Zhu J Julius

Abstract excerpt

Intermolecular interactions dominate the behavior of signal transduction in various physiological and pathological cell processes, yet assessing these interactions remains a challenging task. Here, this study reports a single-molecule force spectroscopic method that enables functional delineation of two interaction sites (≈35 pN and ≈90 pN) between signaling effectors Ras and BRaf in the canonical...

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Identifiers

PMID: 28809097
DOI: 10.1002/smll.201701972
PMCID: PMC6272124

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