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Article

Cracking the molecular origin of intrinsic tyrosine kinase activity through analysis of pathogenic gain-of-function mutations.

Cell reports - 25 Jul 2013

Chen Huaibin, Huang Zhifeng, Dutta Kaushik, Blais Steven, Neubert Thomas A, Li Xiaokun, Cowburn David, Traaseth Nathaniel J, Mohammadi Moosa

Abstract excerpt

The basal (ligand-independent) kinase activity of receptor tyrosine kinases (RTKs) promotes trans-phosphorylation on activation loop tyrosines upon ligand-induced receptor dimerization, thus upregulating intrinsic kinase activity and triggering intracellular signaling. To understand the molecular...

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Identifiers

PMID: 23871672
DOI: 10.1016/j.celrep.2013.06.025
PMCID: PMC3752781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23871672-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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