Article

Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype

2025-03-28

Abstract excerpt

<title>Abstract</title> <p>Background. The ε4 isoform of apolipoprotein E (ApoE) is the most significant genetic risk factor for Alzheimer’s disease. Glial cells are the main source of ApoE in the brain, and in microglia, the ε4 isoform of ApoE has been shown to impair mitochondrial metabolism and the uptake of lipids and Aβ42. However, whether the ε4 isoform alters autophagy or lysosomal activity in microglia i...

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Literature Corpus work: 5f2eb311-2455-5693-b7a4-1bae9b3bfe1c
DOI: 10.21203/rs.3.rs-6241569/v1

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