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ApoE4 expression disrupts tau uptake, trafficking, and clearance in astrocytes

5 Sept 2023

Abstract excerpt

Tauopathies are a collection of neurodegenerative diseases characterized by the accumulation of pathogenic aggregates of the microtubule-associated protein tau. Despite the prevalence and diversity of tau astrogliopathy in tauopathies, the interactions between astrocytes and tau in the brain, and the influence of neurodegenerative genetic risk factors like the apolipoprotein E4 (apoE4) isoform, are largely...

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PMID: 37668005
DOI: 10.1002/glia.24469

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