Article

Allelic DNA synthesis followed by template switching underlies BRCA1-linked tandem duplication

2024-02-21

Abstract excerpt

Microhomology-mediated short tandem duplication (TD) is among specific mutational signatures associated with BRCA1 -deficient tumors. Several mechanisms have been proposed for its generation, but may not be applicable in repeat-less regions of the human genome. We thus developed a repeat-less TD reporter and a PCR-based site-specific TD assay to analyze short TDs induced by one-ended DNA double strand breaks (DSB...

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Literature Corpus work: 8836b5be-010f-5832-9461-b0aa16b7001a
DOI: 10.1101/2024.02.20.581123

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