Article

DNA nicks induce mutational signatures associated with BRCA1 deficiency

2022-02-10

Abstract excerpt

<title>Abstract</title> <p>Analysis of human cancer genome sequences has revealed specific mutational signatures associated with <italic>BRCA1</italic>-deficient tumors, but the underlying mechanisms remain poorly understood. Here, we show that one-ended DNA double strand breaks (DSBs) converted from CRISPR/Cas9-induced nicks by DNA replication, not two-ended DSBs, cause more characteristic chromosomal aberration...

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Literature Corpus work: 906ac783-ec64-5a6b-b011-95f5e3e4bc37
DOI: 10.21203/rs.3.rs-1280037/v1

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