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Article

Defective BRCA1-mediated DNA end resection drives tandem duplication formation and <i>FANCM</i> synthetic lethality

2026-02-22

Abstract excerpt

<h4> Abstract </h4> BRCA1 -linked cancer genomes contain abundant genome-wide ∼10 kb ‘Group 1’ tandem duplications (TDs) that are drivers of tumorigenesis. Group 1 TD formation is recapitulated at a chromosomal Tus/ Ter site-specific replication fork barrier in DNA end resection-defective mouse embryonic stem (mES) cells lacking Brca1 exon 11. To explore relationships between DNA end resection and Group 1 TD f...

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Literature Corpus work
c5756b21-c6eb-59ee-a827-8804dc45cbe1
DOI
10.64898/2026.02.20.706968
Open publication

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Defective BRCA1-mediated DNA end resection drives tandem duplication formation and <i>FANCM</i> synthetic lethalityDOI 10.64898/2026.02.20.706968
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