Article
Microsatellite break-induced replication generates highly mutagenized extrachromosomal circular DNAs
2024-01-13
Abstract excerpt
Extrachromosomal circular DNAs (eccDNAs) are produced from all regions of the eucaryotic genome. In tumors, highly transcribed eccDNAs have been implicated in oncogenesis, neoantigen production and resistance to chemotherapy. Here we show that unstable microsatellites capable of forming hairpin, triplex, quadruplex and AT-rich structures generate eccDNAs when integrated at a common ectopic site in human cells. The...
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Identifiers and source
- Literature Corpus work
- 96460ba1-9acd-57a4-8e51-cd860043058c
- DOI
- 10.1101/2024.01.12.575055