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Article

Distinct mutation patterns of breast cancer-associated alleles of the HRAS1 minisatellite locus.

Human molecular genetics - 1 Mar 1999

Ding S, Larson G P, Foldenauer K, Zhang G, Krontiris T G

Abstract excerpt

DNA sequence analysis of 130 alleles of the HRAS1 minisatellite has demonstrated that breast cancer-associated variants arise as a consequence of both replication errors and gene conversions. Unlike mutations at other variable number of tandem repeats (VNTRs), high-risk variants of the HRAS1 minisatellite do not demonstrate positional polarity. Instead, most mutations occur at three hotspots, with replication...

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PMID: 9949211
DOI: 10.1093/hmg/8.3.515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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