Distinct mutation patterns of breast cancer-associated alleles of the HRAS1 minisatellite locus.

doi:10.1093/hmg/8.3.515

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Article

Distinct mutation patterns of breast cancer-associated alleles of the HRAS1 minisatellite locus.

Human molecular genetics - 1 Mar 1999

Ding S, Larson G P, Foldenauer K, Zhang G, Krontiris T G

Abstract excerpt

DNA sequence analysis of 130 alleles of the HRAS1 minisatellite has demonstrated that breast cancer-associated variants arise as a consequence of both replication errors and gene conversions. Unlike mutations at other variable number of tandem repeats (VNTRs), high-risk variants of the HRAS1 mini...

Topics

Alleles
Base Sequence
Breast Neoplasms
Case-Control Studies
DNA Primers
DNA, Neoplasm
Female
Humans
Minisatellite Repeats
Molecular Sequence Data
Mutation

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