Article
Heterogenous point mutations in the BRCA1 breast cancer susceptibility gene occur in high frequency at the site of homonucleotide tracts, short repeats and methylatable CpG/CpNpG motifs.
Oncogene - 20 Jun 1996
Rodenhiser D, Chakraborty P, Andrews J, Ainsworth P, Mancini D, Lopes E, Singh S
Abstract excerpt
Heterogeneous mutations in the BRCA1 tumour suppressor gene are responsible for a large percentage of inherited breast cancers as well as breast/ovarian cancers in families with a high incidence of both cancer types. Over a hundred BRCA1 mutations have been reported, but little is known of the me...
Topics
- BRCA1 Protein
- Base Composition
- Base Sequence
- Breast Neoplasms
- CpG Islands
- DNA Transposable Elements
- Female
- Genetic Predisposition to Disease
- Humans
- Methylation
- Microsatellite Repeats
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Neoplasm Proteins