Article

PARP1 regulates the genomic ribonucleotide processing activity of TOP1 to prevent the formation of toxic TOP1-DNA adducts and the associated mutations

2026-04-21

Abstract excerpt

Ribonucleotides are frequently incorporated into the genome during DNA replication and are normally removed by RNase H2. Alternatively, DNA topoisomerase 1 (TOP1) can process genomic ribonucleotides through two sequential cleavage events, generating a 2′,3′-cyclic phosphate-terminated nick and, subsequently, a TOP1 cleavage complex (TOP1cc). In addition, TOP1cc formation can lead to 2- to 5-bp slippage deletions,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 975e46c6-8b1b-5805-a0de-52d33a28e4ed
DOI: 10.64898/2026.04.16.719024

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PARP1 regulates the genomic ribonucleotide processing activity of TOP1 to prevent the formation of toxic TOP1-DNA adducts and the associated mutationsDOI 10.64898/2026.04.16.719024Read

Top1-PARP1 association and beyond: from DNA topology to break repairSemantic proximity Read

Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer TherapySemantic proximity Read

PARP1 roles in DNA repair and DNA replication: The basi(c)s of PARP inhibitor efficacy and resistanceSemantic proximity Read

Signatures of TOP1 transcription-associated mutagenesis in cancer and germline.Semantic proximity Read

TDP1-independent pathways in the process and repair of TOP1-induced DNA damageSemantic proximity Read

Nonclassic Functions of Human Topoisomerase I: Genome-Wide and Pharmacologic AnalysesSemantic proximity Read

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapySemantic proximity Read

CHK1-mediated regulation of TOP1 catalytic activity suppresses replication and transcription-associated genomic instabilitySemantic proximity Read

TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcriptionSemantic proximity Read

Genome Instability Induced by Topoisomerase Misfunction.Semantic proximity Read

Human topoisomerases and their roles in genome stability and organizationSemantic proximity Read

Human TopBP1 Ensures Genome Integrity during Normal S PhaseSemantic proximity Read