Article

Extrachromosomal Telomeres Derived from Excessive Strand Displacements

2023-07-31

Abstract excerpt

Alternative Lengthening of Telomeres (ALT) is a telomere maintenance mechanism mediated by break-induced replication (BIR), evident in approximately 15% of human cancers. A characteristic feature of ALT cancers is the presence of C-circles, circular single-stranded telomeric DNAs composed of C-rich sequences. Despite the fact that extrachromosomal C-rich single-stranded DNAs (ssDNAs), unique to ALT cells, are cons...

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Literature Corpus work: d13a14be-2f56-5f26-b430-847e2a20c4ad
DOI: 10.1101/2023.07.31.551186

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