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TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription

9 Nov 2023

Abstract excerpt

DNA topoisomerase I (TOP1) removes torsional stress by transiently cutting one DNA strand. Such cuts are rejoined by TOP1 but can occasionally become abortive generating permanent protein-linked single strand breaks (SSBs). The repair of these breaks is initiated by tyrosyl-DNA phosphodiesterase 1 (TDP1), a conserved enzyme that unlinks the TOP1 peptide from the DNA break. Additionally, some of these SSBs can...

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PMID: 37945566
DOI: 10.1038/s41467-023-42622-7

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