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TDP1-independent pathways in the process and repair of TOP1-induced DNA damage

22 Jul 2022

Abstract excerpt

Anticancer drugs, such as camptothecin (CPT), trap topoisomerase I (TOP1) on DNA and form TOP1 cleavage complexes (TOP1cc). Alternative repair pathways have been suggested in the repair of TOP1cc. However, how these pathways work with TDP1, a key repair enzyme that specifically hydrolyze the covalent bond between TOP1 catalytic tyrosine and the 3'-end of DNA and contribute to the repair of TOP1cc is poorly...

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PMID: 35869071
DOI: 10.1038/s41467-022-31801-7

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