Article

Aramchol attenuates fibrosis in mouse models of biliary fibrosis and blocks the TGFβ-induced fibroinflammatory mediators in cholangiocytes

2024-11-06

Abstract excerpt

<h4>Background</h4> Fibroinflammatory cholangiopathies, such as primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), are characterized by inflammation and biliary fibrosis, driving disease-related complications. In biliary fibrosis, cholangiocytes activated by transforming growth factor-β (TGFβ) release signals that recruit immune cells to drive inflammation and activate hepatic myofibrobla...

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Literature Corpus work: 881b474a-adbd-582d-ad95-a848d98da190
DOI: 10.1101/2024.11.06.621880

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