Article

Cholangiocyte RUNX1 Orchestrates Fibrogenic and Inflammatory Signaling to Drive Biliary Fibrosis

2026-05-22

Abstract excerpt

<h4>Introduction</h4> Biliary fibrosis and inflammation are central to the pathogenesis of cholangiopathies such as primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC). Inflammatory and fibrogenic stimuli, such as transforming growth factor-β (TGFβ) and lipopolysaccharide (LPS) signaling, drive these processes, but their underlying transcriptional mechanisms in cholangiocytes remain incompl...

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Literature Corpus work: c53f9cd1-c4a7-5079-a6b3-337945a49fd3
DOI: 10.64898/2026.05.20.726667

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