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Relevance of Bile Acids in Cholangiocarcinoma Pathogenesis: Critical Revision and Future Directions

7 Jun 2023

Abstract excerpt

Cholangiocarcinoma (CCA), a highly heterogeneous cancer, is the second most common type of primary liver cancer. It is characterized by resistance to therapy and poor prognosis, with a 5-year survival rate lower than 20%. The pathogenesis of CCA is complex and multifactorial, and in recent years, bile acids (BAs) have been implicated in CCA development and prognosis. BAs belong to a category of amphipathic...

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PMID: 37371045
DOI: 10.3390/cells12121576

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