Article

Blocking necroptosis reduces inflammation and tumor incidence in a mouse model of diet-induced hepatocellular carcinoma

2022-08-05

Abstract excerpt

<h4>Background & Aims</h4> Nonalcoholic fatty liver disease (NAFLD) is one of the etiologies that contribute to hepatocellular carcinoma (HCC), and chronic inflammation is one of the proposed mediators of HCC. As necroptosis is a cell death pathway that induces inflammation, we tested whether necroptosis- induced inflammation contributes to the progression of NAFLD to HCC in a mouse model of diet- induced HCC. <h...

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Literature Corpus work: f7425bd3-8bdc-58fa-b927-e2c152874981
DOI: 10.1101/2022.08.03.502666

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